现代乳癌内分泌治疗新方法(ppt 87页)

现代乳癌内分泌治疗新方法目录：
一、乳癌的治疗手段
二、乳癌内分泌治疗的发展
三、三苯氧胺 （TAM)最重要的乳癌内分泌治疗药物
四、瑞宁得  (Arimidex)比 MA更有效、更安全
五、Arimidex in Breast Cancer
六、The Gold Standard
七、Ongoing AI Adjuvant Trials:   ATAC (Anastrozole)
八、Predefined adverse events Vaginal bleeding
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现代乳癌内分泌治疗新方法内容提要：
ATAC  Summary
Anastrozole is superior to tamoxifen in terms of:
Disease-free survival in:Overall population (HR=0.83)Receptor-positive patients (HR=0.78)
Incidence of contralateral breast cancer in: Overall population (OR=0.42)
Conclusions
Anastrozole is the first and only AI to show superior efficacy and improved tolerability compared with tamoxifen in the treatment of EBC
Overall risk-benefit assessment supports anastrozole becoming the future adjuvant treatment of choice in postmenopausal women
Anastrozole also shows promise for the chemoprevention of breast cancer
Why use an Aromatase Inhibitor?
At least as effective as tamoxifen in ABC
ATAC trial provides early warning on side effects
ATAC trial provides efficacy data in early breast cancer at all endpoints;  striking reduction in contralateral breast cancer events
Very low side-effect profile
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