过敏性紫癜肾损害临床相关因素的探讨(doc 5)

关键词：过敏性
     
    【摘要】  目的  探讨过敏性紫癜（HSP）发生肾损害的临床相关因素。方法  回顾性分析1998年1月～2004年1月收治的58例HSP患儿的临床特点及实验室检查结果，其免疫学检查结果与正常对照组（30例）比较。结果  58例HSP患儿查出肾损害26例（44.8%），肾损组男女比例1.6∶1，紫癜反复16例（61.5%），而胃肠道症状20例（76.9%），其中便血8例（30.8%）；非肾损组32例，男女比例0.52∶1，紫癜反复5例（15.6%），有胃肠道症状8例（25.0%），其中便血1例（3.1%），两组比较差异有显著性。肾损组和非肾损组免疫参数与正常对照组相比，血清IgA、CD8均升高，CD4、CD4/CD8均降低，以肾损组尤为明显。结论  肾损害与性别、紫癜反复、胃肠道症状及其严重程度密切相关，与血清IgA升高及T细胞亚群紊乱程度可能也有一定的关系。
   
    【关键词】  紫癜；过敏性；肾疾病；儿童
   
    A study of clinical correlative factors of Henoch-Schonlein purpura with renal involvement
   
     
    【Abstract】  Objective  To research clinical correlative factors in Henoch-Schonlein purpura （HSP) with renal involvement.Methods  Clinical feature and laboratory results in 58 children with HSP were analysed retrospectively，and their immunological examing results were compared with 30 normal control.Results  In 58 children with HSP，26 cases(44.8%)with renal involvement were found out，in which the ratio of male to female was 1.6∶1.There were 16 cases(61.5%) of purpura relapse，and 20 cases(76.9%) of gastrointestinal symptoms，of which there were 8 cases(30.8%) of bloody stools.On the contrary，32 cases with non-renal involvement were found out，in which the ratio of male to female was 0.52∶1.There were 5 case(15.6%)purpura relapse and 8 cases(25.0%) of gastrointestinal symptoms，of which there was 1 case(3.1%) of bloody stools.The difference between the two groups was significant.Compared with the control in immunological parameters，the serum IgA obviously increased and CD8 increased in both of the two groups，while the CD4 and the ratio of CD4/CD8 decreased in two groups，especially in the renal involvement group.Conclusion  Renal involvement has close relationship with sex，purpura relapse，gastrointestinal symptoms and their severe extent.It may have some relationship with the increasing of serum IgA and disorders of T cell subsets.
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